PORTAL: Pilot study on the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection: a double-blind randomized placebo-controlled trial

BACKGROUND: Major surgical procedures facilitate systemic endotoxinemia and formation of free radicals with subsequent inflammatory changes that can influence the postoperative course. Experimental data suggest that preoperative supraphysiological doses of melatonin, a potent immuno-modulator and an...

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Detalhes bibliográficos
Main Authors: Schemmer, Peter, Nickkholgh, Arash, Schneider, Heinz, Sobirey, Michael, Weigand, Markus, Koch, Moritz, Weitz, Jürgen, Büchler, Markus W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248566/
https://ncbi.nlm.nih.gov/pubmed/18215253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2482-8-2
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