Lethal Accumulation of Guanylic Nucleotides in Saccharomyces cerevisiae HPT1-Deregulated Mutants

Guanylic nucleotide biosynthesis is a conserved and highly regulated process. Drugs reducing GMP synthesis affect the immunological response and mutations enabling guanylic-derivative recycling lead to severe mental retardation. While the effects of decreased GMP synthesis have been well documented,...

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Bibliografske podrobnosti
Main Authors: Breton, Annick, Pinson, Benoît, Coulpier, Fanny, Giraud, Marie-France, Dautant, Alain, Daignan-Fornier, Bertrand
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2008
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248339/
https://ncbi.nlm.nih.gov/pubmed/18245832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.083295
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