Complex two-gene modulation of lung disease severity in children with cystic fibrosis

Although cystic fibrosis (CF) is a monogenic disease, its clinical manifestations are influenced in a complex manner. Severity of lung disease, the main cause of mortality among CF patients, is likely modulated by several genes. The mannose-binding lectin 2 (MBL2) gene encodes an innate immune respo...

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Hauptverfasser: Dorfman, Ruslan, Sandford, Andrew, Taylor, Chelsea, Huang, Baisong, Frangolias, Daisy, Wang, Yongqian, Sang, Richard, Pereira, Lilian, Sun, Lei, Berthiaume, Yves, Tsui, Lap-Chee, Paré, Peter D., Durie, Peter, Corey, Mary, Zielenski, Julian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248329/
https://ncbi.nlm.nih.gov/pubmed/18292811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33754
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