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The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominately unstructured protein

Here, we report the solution structure of ZNF593, a protein identified in a functional study as a negative modulator of the DNA-binding activity of the Oct-2 transcription factor. ZNF593 contains a classic C(2)H(2) zinc finger domain flanked by about 40 disordered residues on each terminus. Although...

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Autors principals: Hayes, Paulette L., Lytle, Betsy L., Volkman, Brian F., Peterson, Francis C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248319/
https://ncbi.nlm.nih.gov/pubmed/18287285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073290408
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