Synthesis and Biological Evaluation of Phosphate Prodrugs of 4-Phospho-d -erythronohydroxamic Acid, an Inhibitor of 6-Phosphogluconate Dehydrogenase

We have previously reported the discovery of potent and selective inhibitors of 6-phosphogluconate dehydrogenase, the third enzyme of the phosphate pentose pathway, from Trypanosoma brucei, the causative organism of human African trypanosomiasis. These inhibitors were charged phosphate derivatives w...

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Main Authors: Ruda, Gian Filippo, Alibu, Vincent P, Mitsos, Christos, Bidet, Olivier, Kaiser, Marcel, Brun, Reto, Barrett, Michael P, Gilbert, Ian H
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2007
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Full Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248282/
https://ncbi.nlm.nih.gov/pubmed/17615587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200700040
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