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Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain

The NMDA antagonist, memantine (Namenda), and the cholinesterase inhibitor, donepezil (Aricept), are currently being used widely, either individually or in combination, for treatment of Alzheimer’s disease (AD). NMDA antagonists have both neuroprotective and neurotoxic properties; the latter is augm...

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Détails bibliographiques
Auteurs principaux: Creeley, Catherine E., Wozniak, David F., Nardi, Anthony, Farber, Nuri B., Olney, John W.
Format: Artigo
Langue:Inglês
Publié: 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246087/
https://ncbi.nlm.nih.gov/pubmed/17112636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.10.020
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