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Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain

The NMDA antagonist, memantine (Namenda), and the cholinesterase inhibitor, donepezil (Aricept), are currently being used widely, either individually or in combination, for treatment of Alzheimer’s disease (AD). NMDA antagonists have both neuroprotective and neurotoxic properties; the latter is augm...

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Detalhes bibliográficos
Main Authors: Creeley, Catherine E., Wozniak, David F., Nardi, Anthony, Farber, Nuri B., Olney, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246087/
https://ncbi.nlm.nih.gov/pubmed/17112636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.10.020
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