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Low levels of mammalian TGF-β1 are protective against malaria parasite infection, a paradox clarified in the mosquito host
Nitric oxide (NO), derived from catalysis of inducible NO synthase (iNOS), limits malaria parasite growth in mammals. Transforming growth factor (TGF)-β1 suppresses iNOS in cells in vitro as well as in vivo in mice, but paradoxically severe malaria in humans is associated with low levels of TGF-β1....
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2245860/ https://ncbi.nlm.nih.gov/pubmed/17920060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2007.08.013 |
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