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3′ to 5′ Exonuclease Activity of Herpes Simplex Virus Type 1 DNA Polymerase Modulates Its Strand Displacement Activity

Using a minicircle DNA primer-template, the wild-type catalytic subunit of herpes simplex virus type 1 (HSV-1) DNA polymerase (pol) was shown to lack significant strand displacement activity with or without its processivity factor, UL42. However, an exonuclease-deficient (exo(−)) pol (D368A) was cap...

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Udgivet i:J Virol
Principais autores: Zhu, Yali, Trego, Kelly S., Song, Liping, Parris, Deborah S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC224577/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12941927/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.18.10147-10153.2003
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