Crystallization and preliminary X-ray diffraction analysis of a myotoxic Lys49-PLA(2) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide

For the first time, a non-catalytic and myotoxic Lys49-PLA(2) (BthTX-I from Bothrops jararacussu venom) has been crystallized with BPB inhibitor. X-ray diffraction data were collected and electron-density calculations showed that the ligand is bound to the His48 residue. BthTX-I with His48 chemicall...

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Auteurs principaux: Marchi-Salvador, D. P., Fernandes, C. A. H., Amui, S. F., Soares, A. M., Fontes, M. R. M.
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2006
Sujets:
Crystallization Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2243104/
https://ncbi.nlm.nih.gov/pubmed/16754993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430910601801X
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