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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

Although an excitotoxic mechanism of neuronal injury has been proposed to play a role in chronic neurodegenerative disorders such as Alzheimer’s disease, and neurotrophic factors have been put forward as potential therapeutic agents, direct evidence is lacking. Taking advantage of the fact that muta...

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Sparad:
I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Guo, Qing, Sebastian, Lois, Sopher, Bryce L., Miller, Miles W., Glazner, Gordon W., Ware, Carol B., Martin, George M., Mattson, Mark P.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 1999
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22431/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097174/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.4125
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