A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India. Infection from CHIKV typically induces a mild disease in humans, characterized by fever, myalgia, arthralgia, and rash. Cases of severe CHIKV infection invo...

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Main Authors: Couderc, Thérèse, Chrétien, Fabrice, Schilte, Clémentine, Disson, Olivier, Brigitte, Madly, Guivel-Benhassine, Florence, Touret, Yasmina, Barau, Georges, Cayet, Nadège, Schuffenecker, Isabelle, Desprès, Philippe, Arenzana-Seisdedos, Fernando, Michault, Alain, Albert, Matthew L, Lecuit, Marc
格式: Artigo
語言:Inglês
出版: Public Library of Science 2008
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242832/
https://ncbi.nlm.nih.gov/pubmed/18282093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0040029
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