Integrin αIIbβ3:ligand interactions are linked to binding-site remodeling

This study tested the hypothesis that high-affinity binding of macromolecular ligands to the αIIbβ3 integrin is tightly coupled to binding-site remodeling, an induced-fit process that shifts a conformational equilibrium from a resting toward an open receptor. Interactions between αIIbβ3 and two mode...

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Autors principals: Hantgan, Roy R., Stahle, Mary C., Connor, John H., Horita, David A., Rocco, Mattia, McLane, Mary A., Yakovlev, Sergiy, Medved, Leonid
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242588/
https://ncbi.nlm.nih.gov/pubmed/16877710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.052049506
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