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Integrin αIIbβ3:ligand interactions are linked to binding-site remodeling
This study tested the hypothesis that high-affinity binding of macromolecular ligands to the αIIbβ3 integrin is tightly coupled to binding-site remodeling, an induced-fit process that shifts a conformational equilibrium from a resting toward an open receptor. Interactions between αIIbβ3 and two mode...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242588/ https://ncbi.nlm.nih.gov/pubmed/16877710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.052049506 |
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