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Nogo goes in the pure water: Solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration

The inability to determine the structure of the buffer-insoluble Nogo extracellular domain retarded further design of Nogo receptor (NgR) antagonists to treat CNS axonal injuries. Very surprisingly, we recently discovered that Nogo-60 was soluble and structured in salt-free water, thus allowing the...

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Bibliografske podrobnosti
Main Authors: Li, Minfen, Liu, Jingxian, Song, Jianxing
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242580/
https://ncbi.nlm.nih.gov/pubmed/16877707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062306906
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