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Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter

The human serotonin transporter (hSERT) regulates neurotransmission by removing released serotonin (5-HT) from the synapse. Previous studies identified residues in SERT transmembrane helices (TMHs) I and III as interaction sites for substrates and antagonists. Despite an abundance of data supporting...

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Detalhes bibliográficos
Main Authors: White, Kellie J., Kiser, Philip D., Nichols, David E., Barker, Eric L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242390/
https://ncbi.nlm.nih.gov/pubmed/17008722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062386106
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