A Point Mutation in the Two-Component Regulator PhoP-PhoR Accounts for the Absence of Polyketide-Derived Acyltrehaloses but Not That of Phthiocerol Dimycocerosates in Mycobacterium tuberculosis H37Ra

Similarities between Mycobacterium tuberculosis phoP-phoR mutants and the attenuated laboratory strain M. tuberculosis H37Ra in terms of morphological and cytochemical properties, lipid content, gene expression and virulence attenuation prompted us to analyze the functionality of this two-component...

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Autori principali: Chesne-Seck, Marie-Laure, Barilone, Nathalie, Boudou, Frédéric, Asensio, Jesús Gonzalo, Kolattukudy, Pappachan E., Martín, Carlos, Cole, Stewart T., Gicquel, Brigitte, Gopaul, Deshmukh N., Jackson, Mary
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Genetics and Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2238218/
https://ncbi.nlm.nih.gov/pubmed/18065542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01465-07
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