A Point Mutation in the Two-Component Regulator PhoP-PhoR Accounts for the Absence of Polyketide-Derived Acyltrehaloses but Not That of Phthiocerol Dimycocerosates in Mycobacterium tuberculosis H37Ra

Similarities between Mycobacterium tuberculosis phoP-phoR mutants and the attenuated laboratory strain M. tuberculosis H37Ra in terms of morphological and cytochemical properties, lipid content, gene expression and virulence attenuation prompted us to analyze the functionality of this two-component...

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Autors principals: Chesne-Seck, Marie-Laure, Barilone, Nathalie, Boudou, Frédéric, Asensio, Jesús Gonzalo, Kolattukudy, Pappachan E., Martín, Carlos, Cole, Stewart T., Gicquel, Brigitte, Gopaul, Deshmukh N., Jackson, Mary
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Genetics and Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2238218/
https://ncbi.nlm.nih.gov/pubmed/18065542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01465-07
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