Loading...
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
At high concentrations, the tubule poison paclitaxel is able to kill cancer cells that express Bcl-2; it inhibits the antiapoptotic activity of Bcl-2 by inducing its phosphorylation. To localize the site on Bcl-2 regulated by phosphorylation, mutant forms of Bcl-2 were constructed. Mutant forms of B...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The National Academy of Sciences
1999
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC22370/ https://ncbi.nlm.nih.gov/pubmed/10097113 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|