Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer

Because of its low toxicity, low-dose (LD) chemotherapy is ideally suited for combination with antiangiogenic drugs. We investigated the impact of tumor vascular endothelial growth factor A (VEGF-A) expression on the efficacy of LD paclitaxel chemotherapy and its interactions with the tyrosine kinas...

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Detalhes bibliográficos
Main Authors: Holtz, David O, Krafty, Robert T, Mohamed-Hadley, Alisha, Zhang, Lin, Alagkiozidis, Ioannis, Leiby, Benjamin, Guo, Wensheng, Gimotty, Phyllis A, Coukos, George
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2235830/
https://ncbi.nlm.nih.gov/pubmed/18182107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-2
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