Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis

Severe congenital neutropenia (SCN) is an inborn disorder of granulopoiesis. Mutations of the ELA2 gene encoding neutrophil elastase (NE) are responsible for most cases of SCN and cyclic neutropenia (CN), a related but milder disorder of granulopoiesis. However, the mechanisms by which these mutatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Grenda, David S., Murakami, Mark, Ghatak, Jhuma, Xia, Jun, Boxer, Laurence A., Dale, David, Dinauer, Mary C., Link, Daniel C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2007
Pynciau:
Hematopoiesis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234798/
https://ncbi.nlm.nih.gov/pubmed/17761833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-057299
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