INHIBITION OF HUMAN BRAIN PYRUVATE KINASE AND HEXOKINASE BY PHENYLALANINE AND PHENYLPYRUVATE: POSSIBLE RELEVANCE TO PHENYLKETONURIC BRAIN DAMAGE
In phenylketonuria high levels of L-phenylalanine are present along with increased levels of phenylpyruvic acid. The present work shows that L-phenylalanine is a competitive inhibitor of human brain pyruvate kinase and phenylpyruvic acid is an inhibitor of human brain hexokinase. The enzymes have ap...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1969
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223473/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5260939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.63.4.1365 |
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