PEPTIDYL TRANSFERS IN GRAMICIDIN S BIOSYNTHESIS FROM ENZYME-BOUND THIOESTER INTERMEDIATES

The biosynthesis of the peptide antibiotic gramicidin S involves successive peptidyl transfer reactions between intermediates bound in thioester linkages to two active enzyme fractions, I and II. Fraction II activates and recemizes phenylalanine, and then initiates peptidyl transfer by catalyzing a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gevers, Wieland, Kleinkauf, Horst, Lipmann, Fritz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1969
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5260936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.63.4.1335
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