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Computational analysis of splicing errors and mutations in human transcripts

BACKGROUND: Most retained introns found in human cDNAs generated by high-throughput sequencing projects seem to result from underspliced transcripts, and thus they capture intermediate steps of pre-mRNA splicing. On the other hand, mutations in splice sites cause exon skipping of the respective exon...

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Autori principali: Kurmangaliyev, Yerbol Z, Gelfand, Mikhail S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234086/
https://ncbi.nlm.nih.gov/pubmed/18194514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-13
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