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Mechanism of Block of hEag1 K(+) Channels by Imipramine and Astemizole
Ether à go-go (Eag; K(V)10.1) voltage-gated K(+) channels have been detected in cancer cell lines of diverse origin and shown to influence their rate of proliferation. The tricyclic antidepressant imipramine and the antihistamine astemizole inhibit the current through Eag1 channels and reduce the pr...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2233905/ https://ncbi.nlm.nih.gov/pubmed/15365094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409041 |
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