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Extracellular Blockade of K(+) Channels by Tea: Results from Molecular Dynamics Simulations of the Kcsa Channel

TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to the pore (Heginbotham, L., and R. MacKinnon. 1...

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Hlavní autoři: Crouzy, Serge, Bernèche, Simon, Roux, Benoît
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233828/
https://ncbi.nlm.nih.gov/pubmed/11479347
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