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Ryanoid Modification of the Cardiac Muscle Ryanodine Receptor Channel Results in Relocation of the Tetraethylammonium Binding Site

The interaction of ryanodine and derivatives of ryanodine with the high affinity binding site on the ryanodine receptor (RyR) channel brings about a characteristic modification of channel function. In all cases, channel open probability increases dramatically and single-channel current amplitude is...

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Détails bibliographiques
Auteurs principaux: Tanna, Bhavna, Welch, William, Ruest, Luc, Sutko, John L., Williams, Alan J.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233661/
https://ncbi.nlm.nih.gov/pubmed/11331348
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