Resveratrol Inhibits Expression and Binding Activity of the Monocyte Chemotactic Protein-1 Receptor, CCR2, on THP-1 Monocytes

Monocyte chemotactic protein-1 and its receptor, CCR2, play a key role in atherosclerosis. We determined the effect of the polyphenol, resveratrol, on CCR2 and the mechanisms involved. Resveratrol treatment inhibited (125)I-MCP-1 binding to THP-1 cells; 31%, 56%, 84% decrease for 10, 50 and 100 µM r...

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Detalhes bibliográficos
Main Authors: Cullen, John P., Morrow, David, Jin, Ying, von Offenberg Sweeney, Nicholas, Sitzmann, James V., Cahill, Paul A., Redmond, Eileen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2231518/
https://ncbi.nlm.nih.gov/pubmed/17499741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.03.039
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