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Signaling Crossroads: The function of Raf Kinase Inhibitory Protein in Cancer, the Central Nervous System and Reproduction
The Raf kinase inhibitory protein 1 (RKIP-1) and its orthologs are conserved throughout evolution and widely expressed in eukaryotic organisms. In its non-phosphorylated form RKIP-1 negatively regulates the Raf/MEK/ERK pathway by interfering with the activity of Raf-1. In its phosphorylated state, R...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2231335/ https://ncbi.nlm.nih.gov/pubmed/17706925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.07.003 |
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