Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje cells. Ionizing radiation oxidizes macromolecules and causes tissue damage through the generation of rea...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449794/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9915 |
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