Calcium Wave Propagation in Pancreatic Acinar Cells: Functional Interaction of Inositol 1,4,5-Trisphosphate Receptors, Ryanodine Receptors, and Mitochondria

In pancreatic acinar cells, inositol 1,4,5-trisphosphate (InsP(3))–dependent cytosolic calcium ([Ca(2+)](i)) increases resulting from agonist stimulation are initiated in an apical “trigger zone,” where the vast majority of InsP(3) receptors (InsP(3)R) are localized. At threshold stimulation, [Ca(2+...

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Main Authors: Straub, Stephen V., Giovannucci, David R., Yule, David I.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2000
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230627/
https://ncbi.nlm.nih.gov/pubmed/11004204
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