Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium.

BACKGROUND: Synovia of patients with long-standing rheumatoid arthritis (RA) are typically infiltrated with B lymphocytes and plasma cells that secrete large amounts of immunoglobulin. The CDR3 of an immunoglobulin heavy chain is composed of the VH-DH-JH join, with interposed N region addition, and...

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Main Authors: Clausen, B. E., Bridges, S. L., Lavelle, J. C., Fowler, P. G., Gay, S., Koopman, W. J., Schroeder, H. W.
Format: Artigo
Sprog:Inglês
Udgivet: The Feinstein Institute for Medical Research 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230361/
https://ncbi.nlm.nih.gov/pubmed/9606177
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