Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin.

BACKGROUND: Lipopolysaccharides (LPS), widely used to study the mechanisms of gram-negative sepsis, increase airway resistance by constriction of terminal bronchioles. The role of the cyclooxygenase (COX) isoenzymes and their prostanoid metabolites in this process was studied. MATERIALS AND METHODS:...

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Autori principali: Uhlig, S., Nüsing, R., von Bethmann, A., Featherstone, R. L., Klein, T., Brasch, F., Müller, K. M., Ullrich, V., Wendel, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Feinstein Institute for Medical Research 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230144/
https://ncbi.nlm.nih.gov/pubmed/8784790
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