Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation.

BACKGROUND: We previously demonstrated the local production of the pleiotropic cytokine interleukin-6 (IL-6) in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis. MATERIALS AND METHODS: To assess the role of...

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Bibliographic Details
Main Authors: Gijbels, K., Brocke, S., Abrams, J. S., Steinman, L.
Format: Artigo
Language:Inglês
Published: The Feinstein Institute for Medical Research 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230023/
https://ncbi.nlm.nih.gov/pubmed/8612202
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