Amyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptide.

BACKGROUND: Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the beta cells of the islets of Langerhans should be useful in identifying factors important for the deposition of IAPP as insoluble amyloid fibrils. MATERIALS AND METHOD...

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Main Authors: Westermark, G., Arora, M. B., Fox, N., Carroll, R., Chan, S. J., Westermark, P., Steiner, D. F.
Formato: Artigo
Idioma:Inglês
Publicado: The Feinstein Institute for Medical Research 1995
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229964/
https://ncbi.nlm.nih.gov/pubmed/8529120
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