Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.

BACKGROUND: Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these cytokines is tumor necrosis factor (TNF). Details of the signaling pathway leading to TNF biosynt...

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Bibliografiske detaljer
Main Authors: Geppert, T. D., Whitehurst, C. E., Thompson, P., Beutler, B.
Format: Artigo
Sprog:Inglês
Udgivet: The Feinstein Institute for Medical Research 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229930/
https://ncbi.nlm.nih.gov/pubmed/8790605
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