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Regulation of K(+) Flow by a Ring of Negative Charges in the Outer Pore of BK(Ca) Channels. Part I: Aspartate 292 modulates K(+) Conduction by External Surface Charge Effect
The pore region of the majority of K(+) channels contains the highly conserved GYGD sequence, known as the K(+) channel signature sequence, where the GYG is critical for K(+) selectivity (Heginbotham, L., T. Abramson, and R. MacKinnon. 1992. Science. 258:1152–1155). Exchanging the aspartate residue...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229624/ https://ncbi.nlm.nih.gov/pubmed/15277578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308949 |
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