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A monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic GMP pathway in frog rod outer segments

A monoclonal antibody that blocks the light-activated cyclic GMP (cGMP) pathway in frog photoreceptor outer segments (ROS) has been obtained. The antibody (4A) inhibits guanine nucleotide binding to G-protein, the intermediate that links rhodopsin excitation to cGMP phosphodiesterase (PDE), inhibiti...

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Bibliografiske detaljer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1984
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228732/
https://ncbi.nlm.nih.gov/pubmed/6092516
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