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Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8(+) T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

Tumor cells gene-modified to produce GM-CSF potently stimulate antitumor immune responses, in part, by causing the growth and differentiation of dendritic cells (DC). However, GM-CSF-modified tumor cells must be γ-irradiated or they will grow progressively, killing the host. We observed that 23 of 7...

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Autors principals: Bronte, Vincenzo, Chappell, Dale B., Apolloni, Elisa, Cabrelle, Anna, Wang, Michael, Hwu, Patrick, Restifo, Nicholas P.
Format: Artigo
Idioma:Inglês
Publicat: 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228333/
https://ncbi.nlm.nih.gov/pubmed/10229805
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