Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase

BACKGROUND: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive targ...

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Autori principali: Monzani, Paulo S, Trapani, Stefano, Thiemann, Otavio H, Oliva, Glaucius
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228302/
https://ncbi.nlm.nih.gov/pubmed/17894860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-59
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