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Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase
BACKGROUND: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive targ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2228302/ https://ncbi.nlm.nih.gov/pubmed/17894860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-59 |
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