Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.

Haematoporphyrin derivatives (HPDs) are potent sensitizers in photodynamic therapy (PDT), associated with prolonged skin photosensitivity. 5-Aminolaevulinic acid (5-ALA), a natural precusor of haem, is converted intracellularly into the photosensitive agent protoporphyrin IX (PPIX), causing direct c...

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Hauptverfasser: Messmann, H., Geisler, M., Gross, U., Abels, C., Szeimies, R. M., Steinbach, P., Knüchel, R., Doss, M., Schölmerich, J., Holstege, A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228054/
https://ncbi.nlm.nih.gov/pubmed/9328146
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