Stereoselective peripheral sensory neurotoxicity of diaminocyclohexane platinum enantiomers related to ormaplatin and oxaliplatin.

The diaminocyclohexane platinum (Pt(DACH)) derivatives ormaplatin and oxaliplatin have caused severe and dose-limiting peripheral sensory neurotoxicity in a clinical trial. We hypothesized that this toxicity could vary in relation to the biotransformation and stereochemistry of these Pt(DACH) deriva...

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Autori principali: Screnci, D., Er, H. M., Hambley, T. W., Galettis, P., Brouwer, W., McKeage, M. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2227979/
https://ncbi.nlm.nih.gov/pubmed/9275028
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