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Enhancer competition between H19 and Igf2 does not mediate their imprinting

The linked H19 and Igf2 genes on mouse distal chromosome 7 are subject to genomic imprinting. Competition between the promoters of the genes for transcription from shared enhancers has been proposed as an explanation for the coordinate expression and reciprocal imprinting of these two genes. To test...

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Autors principals: Schmidt, Jennifer V., Levorse, John M., Tilghman, Shirley M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC22279/
https://ncbi.nlm.nih.gov/pubmed/10449763
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