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Na(+) Occupancy and Mg(2+) Block of the N-Methyl-d-Aspartate Receptor Channel

The effect of extracellular and intracellular Na(+) on the single-channel kinetics of Mg(2+) block was studied in recombinant NR1-NR2B NMDA receptor channels. Na(+) prevents Mg(2+) access to its blocking site by occupying two sites in the external portion of the permeation pathway. The occupancy of...

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Detalhes bibliográficos
Main Authors: Zhu, Yongling, Auerbach, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225621/
https://ncbi.nlm.nih.gov/pubmed/11222630
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