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Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitrite

Homocysteine (HCY) is toxic on blood vessels, but a potential direct toxicity of HCY on the heart is unknown. We addressed this issue by exposing H9C2 cardiomyocytes to HCY (0.1–5 mM) for up to 6 h. At these concentrations, HCY reduced cell viability, induced necrosis and apoptosis and triggered the...

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Bibliografski detalji
Glavni autori: Levrand, Sandra, Pacher, Pal, Pesse, Benoît, Rolli, Joelle, Feihl, François, Waeber, Bernard, Liaudet, Lucas
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225538/
https://ncbi.nlm.nih.gov/pubmed/17544363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.147
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