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Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitrite
Homocysteine (HCY) is toxic on blood vessels, but a potential direct toxicity of HCY on the heart is unknown. We addressed this issue by exposing H9C2 cardiomyocytes to HCY (0.1–5 mM) for up to 6 h. At these concentrations, HCY reduced cell viability, induced necrosis and apoptosis and triggered the...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2225538/ https://ncbi.nlm.nih.gov/pubmed/17544363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.147 |
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