Clonal Focusing of Epitope-Specific CD8(+) T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge

To afford the greatest possible immune protection, candidate human immunodeficiency virus (HIV) vaccines must generate diverse and long-lasting CD8(+) T lymphocyte responses. In the present study, we evaluate T-cell receptor Vβ (variable region beta) gene usage and a CDR3 (complementarity-determinin...

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Detalhes bibliográficos
Main Authors: Sen, Pritha, Charini, William A., Subbramanian, Ramu A., Manuel, Edwin R., Kuroda, Marcelo J., Autissier, Patrick A., Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224610/
https://ncbi.nlm.nih.gov/pubmed/17977967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01038-07
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