Evolution to Pathogenicity of the Parvovirus Minute Virus of Mice in Immunodeficient Mice Involves Genetic Heterogeneity at the Capsid Domain That Determines Tropism

Very little is known about the role that evolutionary dynamics plays in diseases caused by mammalian DNA viruses. To address this issue in a natural host model, we compared the pathogenesis and genetics of the attenuated fibrotropic and the virulent lymphohematotropic strains of the parvovirus minut...

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Bibliographic Details
Main Authors: López-Bueno, Alberto, Segovia, José C., Bueren, Juan A., O'Sullivan, M. Gerard, Wang, Feng, Tattersall, Peter, Almendral, José M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224436/
https://ncbi.nlm.nih.gov/pubmed/18045943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01692-07
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