The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp

The accessory subunit of the heterodimeric mtDNA polymerase (polγ) from Drosophila embryos is required to maintain the structural integrity or catalytic efficiency of the holoenzyme. cDNAs for the accessory subunit from Drosophila, man, mouse, and rat have been identified, and comparative sequence a...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Fan, Li, Sanschagrin, Paul C., Kaguni, Laurie S., Kuhn, Leslie A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9527
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