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Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients.

The cytotoxic activity and cross-resistance pattern of the novel topoisomerase I inhibitor topotecan (Topo) were investigated in ten cell lines, representing different mechanisms of cytotoxic drug resistance, and in 218 fresh human tumour samples using the fluorometric microculture cytotoxicity assa...

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Main Authors: Jonsson, E., Fridborg, H., Csóka, K., Dhar, S., Sundström, C., Nygren, P., Larsson, R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223940/
https://ncbi.nlm.nih.gov/pubmed/9231921
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