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K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer.

We examined 159 consecutive cases of non-small-cell lung cancer (NSCLC) for a mutation at codon 12 of the K-ras gene and for a mutation of the p53 gene occurring in exons 5-8. Eleven (6.9%) had mutations of the K-ras (ras+) and 57 (35.8%) had mutations of the p53 (p53+). There were 95 cases (59.7%)...

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Main Authors: Fukuyama, Y., Mitsudomi, T., Sugio, K., Ishida, T., Akazawa, K., Sugimachi, K.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222780/
https://ncbi.nlm.nih.gov/pubmed/9099959
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