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Ligand-insensitive State of Cardiac ATP-sensitive K(+) Channels : Basis for Channel Opening

The mechanism by which ATP-sensitive K(+) (K(ATP)) channels open in the presence of inhibitory concentrations of ATP remains unknown. Herein, using a four-state kinetic model, we found that the nucleotide diphosphate UDP directed cardiac K(ATP) channels to operate within intraburst transitions. Thes...

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Bibliographic Details
Main Authors: Alekseev, Alexey E., Brady, Peter A., Terzic, Andre
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1998
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222775/
https://ncbi.nlm.nih.gov/pubmed/9450949
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