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Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA’s beneficial actions and therefore are of int...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Clish, Clary B., O’Brien, Jennifer A., Gronert, Karsten, Stahl, Gregory L., Petasis, Nicos A., Serhan, Charles N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22220/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10393980/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.14.8247
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